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Year : 2022  |  Volume : 9  |  Issue : 2  |  Page : 51-57

The effects of flavonoids in curcumin on neurobehavioral deficits in insulin-resistant rats

1 Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University, Osogbo, Osun, Nigeria
2 Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Kwara, Nigeria

Correspondence Address:
Abdullahi Abiodun Mohammed
Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University, Osogbo, Osun
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jnbs.jnbs_17_22

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Background: Diabetes mellitus is a risk factor for dementia, particularly Alzheimer's disease (AD). In a Wistar rat model, we studied Alzheimer-like symptoms using a high-fat diet (HFD) and streptozotocin (STZ) to replicate insulin resistance and the resulting neurobehavioral abnormalities. Curcumin, a flavonoid in turmeric, was studied for its potential therapeutic effects. Aim: This study sought to look at the exploratory, discriminatory, and spatial cognitive indices in rats. Materials and Methods: Thirty-six male Wistar rats were randomized into six groups and given the following treatments: olive oil only for control; curcumin only for the curcumin group; HFD and three doses STZ for the diabetic rats; HFD, three doses STZ, and concurrent treatment with curcumin for the protective group; pretreatment with curcumin, then HFD and three doses STZ for a preventive group; and HFD, three doses STZ, and curcumin for a therapeutic group. Subsequently, line and center line crossing frequency assessed rats' exploratory activities; rearing frequency data assessed novel environment behavior. The novel object recognition test and Morris water maze test assessed discrimination and spatial memory. Data were analyzed using one-way analysis of variance and Tukey's post hoc test. P < 0.05 was considered statistically significant. Results: Our findings revealed that insulin resistance prolonged escape latency of untreated diabetic rats; contrariwise, curcumin significantly reduced escape latency, increased difference score in novel object recognition paradigm, and increased explorative activities. Conclusion: Oral curcumin improves exploratory activity, discriminating memory, and spatial memory in male Wistar rats with AD-like neurobehavioral impairments. Patients with neurobehavioral abnormalities and comorbid insulin resistance may benefit from the flavonoids in curcumin.

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