• Users Online: 176
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2022  |  Volume : 9  |  Issue : 2  |  Page : 51-57

The effects of flavonoids in curcumin on neurobehavioral deficits in insulin-resistant rats


1 Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University, Osogbo, Osun, Nigeria
2 Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Kwara, Nigeria

Correspondence Address:
Abdullahi Abiodun Mohammed
Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University, Osogbo, Osun
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jnbs.jnbs_17_22

Rights and Permissions

Background: Diabetes mellitus is a risk factor for dementia, particularly Alzheimer's disease (AD). In a Wistar rat model, we studied Alzheimer-like symptoms using a high-fat diet (HFD) and streptozotocin (STZ) to replicate insulin resistance and the resulting neurobehavioral abnormalities. Curcumin, a flavonoid in turmeric, was studied for its potential therapeutic effects. Aim: This study sought to look at the exploratory, discriminatory, and spatial cognitive indices in rats. Materials and Methods: Thirty-six male Wistar rats were randomized into six groups and given the following treatments: olive oil only for control; curcumin only for the curcumin group; HFD and three doses STZ for the diabetic rats; HFD, three doses STZ, and concurrent treatment with curcumin for the protective group; pretreatment with curcumin, then HFD and three doses STZ for a preventive group; and HFD, three doses STZ, and curcumin for a therapeutic group. Subsequently, line and center line crossing frequency assessed rats' exploratory activities; rearing frequency data assessed novel environment behavior. The novel object recognition test and Morris water maze test assessed discrimination and spatial memory. Data were analyzed using one-way analysis of variance and Tukey's post hoc test. P < 0.05 was considered statistically significant. Results: Our findings revealed that insulin resistance prolonged escape latency of untreated diabetic rats; contrariwise, curcumin significantly reduced escape latency, increased difference score in novel object recognition paradigm, and increased explorative activities. Conclusion: Oral curcumin improves exploratory activity, discriminating memory, and spatial memory in male Wistar rats with AD-like neurobehavioral impairments. Patients with neurobehavioral abnormalities and comorbid insulin resistance may benefit from the flavonoids in curcumin.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed502    
    Printed12    
    Emailed0    
    PDF Downloaded64    
    Comments [Add]    

Recommend this journal