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Year : 2020  |  Volume : 7  |  Issue : 3  |  Page : 170-173

Distribution of Dopamine Receptor 2 (DRD2) rs1800497 Polymorphisms In Cyclist

1 Marmara University Faculty of Dentistry Basic Medical Sciences, Medical Biology and Genetics, Istanbul, Turkey
2 Nisantası University, School of Physical Education and Sports, Istanbul, Turkey
3 Uskudar University, Laboratory of Medical Genetics and Molecular Diagnostics, Istanbul, Turkey

Correspondence Address:
Korkut Ulucan
Haluk Türksoy Sokak No: 14, Altunizade 34662, İstanbul
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jnbs.jnbs_34_20

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Genetic and environmental factors are important determinants of the athletic performance. Sports genetic determines certain alleles for the identification of the genes that affect athletic performance. Comprehensive researches including the biology of mental properties are accumulating due to the improvement of the information of molecular biology. Dopamine is an important neurotransmitter of the dopaminergic system that affects the athlete mentally and psychologically. In this study, our goal is to determine the genotype and allele distributions of the DRD2 rs180047 polymorphism in the cyclists. Nineteen cyclists and 52 sedentary individuals (controls) participated in our study. Genotyping was carried out by real-time polymerase chain reaction after DNA was isolated from buccal epithelial cells. In our cohort, AG and GG genotypes were detected as 6 (32%) and 13 (68%), respectively. In the control group, the respective AA, AG, and GG genotypes were detected as 9 (17%), 18 (35%), and 25 (48%). No statistically significant difference was detected in terms of genotype distribution between the two groups (P=0.1107). When allelic distributions were examined, in the athlete cohort, A and G allele numbers were counted as 6 (16%) and 32 (84%), respectively. In the control group, the same alleles were counted as 36 (35%) and 68 (65%). There was no statistically significant difference in terms of alleles in our study cohort (P = 0.0295). In our cohort, GG genotype and the G allele of the DRD2 rs1800497 polymorphism were dominant. Recent studies showed the association of the A allele with addiction. Therefore, we hypothesized the association of the related allele and success in cyclists. Although we were unable to find a statistically significant difference, we suggest to analyze the same polymorphism in athletes with different sports branches to fulfill the role of the given polymorphism.

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